Lace M. Riggs, M.A.
GRADUATE STUDENT PROGRAM IN NEUROSCIENCE
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Education
M.A. in Experimental Psychology, California State University, San Bernardino, CA B.A. in Biological Psychology, California State University, San Bernardino, CA Current Projects Examining the pharmacodynamics of ketamine and its metabolites. Other Research Interests Neurodevelopment, epigenetics, neuroinflammation, addiction, research ethics, health disparities, diversity. Contact Information Email: lacemriggs[at]umaryland.edu Phone: (410) 706-6799 |
Description
I earned my B.A. in Biological Psychology and my M.A. in Experimental Psychology from California State University (San Bernardino, CA). There, my research focused on the role of chronic stress in adolescent-onset depression, as well as the age-dependent neurobehavioral outcomes associated with traditional and rapid-acting antidepressants. I have had a persistent interest in the etiology of psychiatric disease, with a growing passion for translational approaches that provide mechanistic insight in favor of advancing novel therapeutic development. This led me to the Gould Lab, where I am currently using behavioral, electrophysiological, and photometric approaches to investigate the mechanistic basis for the rapid antidepressant actions of (2R,6R)-hydroxynorketamine.
I earned my B.A. in Biological Psychology and my M.A. in Experimental Psychology from California State University (San Bernardino, CA). There, my research focused on the role of chronic stress in adolescent-onset depression, as well as the age-dependent neurobehavioral outcomes associated with traditional and rapid-acting antidepressants. I have had a persistent interest in the etiology of psychiatric disease, with a growing passion for translational approaches that provide mechanistic insight in favor of advancing novel therapeutic development. This led me to the Gould Lab, where I am currently using behavioral, electrophysiological, and photometric approaches to investigate the mechanistic basis for the rapid antidepressant actions of (2R,6R)-hydroxynorketamine.
funding
Current
T32 GM008181, Training Program in Integrative Membrane Biology, National Institutes of Health, National Institute of General Medical Sciences, University of Maryland School of Medicine, Baltimore MD.
Previous
T32 NS063391, Student of Merit, Training Program in Neuroscience, National Institutes of Health, National Institute of Neurological Disorders and Stroke, University of Maryland School of Medicine, Baltimore MD.
R25 GM055036, Meyerhoff Graduate Fellow, National Institutes of Health, Initiative for Maximizing Student Development, University of Maryland School of Medicine, Baltimore MD.
R24 DA033877, Predoctoral Fellow, National Institute on Drug Abuse, Diversity Promoting Institutions Drug Abuse Research Program, California State University, San Bernardino CA.
T32 GM008181, Training Program in Integrative Membrane Biology, National Institutes of Health, National Institute of General Medical Sciences, University of Maryland School of Medicine, Baltimore MD.
Previous
T32 NS063391, Student of Merit, Training Program in Neuroscience, National Institutes of Health, National Institute of Neurological Disorders and Stroke, University of Maryland School of Medicine, Baltimore MD.
R25 GM055036, Meyerhoff Graduate Fellow, National Institutes of Health, Initiative for Maximizing Student Development, University of Maryland School of Medicine, Baltimore MD.
R24 DA033877, Predoctoral Fellow, National Institute on Drug Abuse, Diversity Promoting Institutions Drug Abuse Research Program, California State University, San Bernardino CA.
selected publications
Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD (2018). Ketamine and ketamine metabolite pharmacology: Insights into therapeutic mechanisms. Pharmacological Reviews, 70(3):621-660. PMID: 29945898.
Chandra R*, Engeln M*, Schiefer C, Patton MH, Martin JA, Werner CT, Riggs LM, Francis TC, McGlincy M, Evans BB, Nam H, Das S, Girven K, Konkalmatt P, Gancarz AM, Golden SA, Iñiguez SD, Russo SJ, Turecki G, Mathur BN, Creed M, Dietz DM, Lobo MK (2017). Drp1 mitochondrial fission in D1 neurons mediates behavioral and cellular plasticity during early cocaine abstinence. Neuron, 96(6):1327-1341. *Shared First Author. PMID: 29268097.
Iñiguez SD, Flores-Ramirez FJ, Riggs LM, Alipio JB, Garcia I, Hernandez M, Sanchez DO, Lobo MK, Serrano PA, Braren SH, Castillo SA (2017). Vicarious social defeat stress induces depression-related outcomes in female mice. Biological Psychiatry, 83(1):9-17. PMID: 28888327.
Chandra R, Francis TC, Nam H, Riggs LM, Engeln M, Rudzinskas S, Konkalmatt P, Russo S, Turecki G, Iñiguez SD, Lobo MK (2017). Reduced Slc6a15 in nucleus accumbens D2-neurons underlies stress susceptibility. Journal of Neuroscience, 37(27):6527-6538. PMID: 28576941.
Iñiguez SD, Aubry A, Riggs LM, Alipio JB, Zanca RM, Flores-Ramirez FJ, Hernandez MA, Nieto SJ, Musheyev D, Serrano PA (2016). Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiology of Stress, 5:54-64. eCollection. PMID: 27981196.
Iñiguez SD, Riggs LM, Nieto SJ, Wright KN, Zamora NN, Cruz B, Zavala AR, Robison AJ, Mazei-Robison MS (2015). Fluoxetine exposure during adolescence increases preference for cocaine in adulthood. Scientific Reports. 5, 15009; doi: 10.1038/srep15009. PMID: 26449406.
Iñiguez SD, Riggs LM, Nieto SJ, Dayrit G, Zamora NN, Shawhan K, Cruz B, Warren BL (2014). Social defeat stress induces a depression-like phenotype in adolescent male C57BL/6 mice. Stress, 17(3):247-255. PMID: 24689732.
Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños-Guzman CA (2014). Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. Journal of Neuroscience, 34(3):1007-1021. PMID: 24431458.
For full list, please visit:
Chandra R*, Engeln M*, Schiefer C, Patton MH, Martin JA, Werner CT, Riggs LM, Francis TC, McGlincy M, Evans BB, Nam H, Das S, Girven K, Konkalmatt P, Gancarz AM, Golden SA, Iñiguez SD, Russo SJ, Turecki G, Mathur BN, Creed M, Dietz DM, Lobo MK (2017). Drp1 mitochondrial fission in D1 neurons mediates behavioral and cellular plasticity during early cocaine abstinence. Neuron, 96(6):1327-1341. *Shared First Author. PMID: 29268097.
Iñiguez SD, Flores-Ramirez FJ, Riggs LM, Alipio JB, Garcia I, Hernandez M, Sanchez DO, Lobo MK, Serrano PA, Braren SH, Castillo SA (2017). Vicarious social defeat stress induces depression-related outcomes in female mice. Biological Psychiatry, 83(1):9-17. PMID: 28888327.
Chandra R, Francis TC, Nam H, Riggs LM, Engeln M, Rudzinskas S, Konkalmatt P, Russo S, Turecki G, Iñiguez SD, Lobo MK (2017). Reduced Slc6a15 in nucleus accumbens D2-neurons underlies stress susceptibility. Journal of Neuroscience, 37(27):6527-6538. PMID: 28576941.
Iñiguez SD, Aubry A, Riggs LM, Alipio JB, Zanca RM, Flores-Ramirez FJ, Hernandez MA, Nieto SJ, Musheyev D, Serrano PA (2016). Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiology of Stress, 5:54-64. eCollection. PMID: 27981196.
Iñiguez SD, Riggs LM, Nieto SJ, Wright KN, Zamora NN, Cruz B, Zavala AR, Robison AJ, Mazei-Robison MS (2015). Fluoxetine exposure during adolescence increases preference for cocaine in adulthood. Scientific Reports. 5, 15009; doi: 10.1038/srep15009. PMID: 26449406.
Iñiguez SD, Riggs LM, Nieto SJ, Dayrit G, Zamora NN, Shawhan K, Cruz B, Warren BL (2014). Social defeat stress induces a depression-like phenotype in adolescent male C57BL/6 mice. Stress, 17(3):247-255. PMID: 24689732.
Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños-Guzman CA (2014). Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. Journal of Neuroscience, 34(3):1007-1021. PMID: 24431458.
For full list, please visit:
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